Trelegy Ellipta: Side effects, dosage, uses, alternatives, and more - Medical News Today

Trelegy Ellipta can interact with several other medications. It's not known to interact with supplements or foods.

Different interactions can cause different effects. For instance, some interactions can interfere with how well a drug works. Other interactions can increase the number of side effects or make them more severe.

Trelegy Ellipta and other medications

Below is a list of medications that can interact with Trelegy Ellipta. This list does not contain all drugs that may interact with Trelegy Ellipta.

Before taking Trelegy Ellipta, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.

If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.

Trelegy Ellipta and Spiriva

You shouldn't take Trelegy Ellipta if you're also taking tiotropium (Spiriva). This is because both of these medications have a drug called an anticholinergic in them. (For more about anticholinergics, see "Trelegy Ellipta and other anticholinergic medications" right below.)

Taking these medications together may increase your risk for side effects. And some of these side effects can become serious, such as overheating or hallucinating. So if you're taking Spiriva, you'll need to stop using it before you start Trelegy Ellipta treatment.

Trelegy Ellipta and other anticholinergic medications

Trelegy Ellipta contains umeclidinium, which is a type of drug called an anticholinergic. If you take umeclidinium with another anticholinergic medication, the drugs' effects can combine and increase your risk for side effects. (For more about possible side effects of Trelegy Ellipta, see the "Trelegy Ellipta side effects" section above.) You shouldn't take Trelegy Ellipta with other anticholinergic medications.

Examples of examples of drugs that contain an anticholinergic medication include:

If you're taking an anticholinergic drug, tell your doctor before you start using Trelegy Ellipta. They may be able to recommend a different medication that doesn't interact with Trelegy Ellipta.

Trelegy Ellipta and certain antimicrobial drugs

Antimicrobial drugs are medications that are used to treat infections. These medications can be used for many different types of infections, such as bacterial, viral, or fungal. Some antimicrobial drugs inhibit (block) the activity of CYP3A4, which is an enzyme that breaks down Trelegy Ellipta. And this can cause the level of Trelegy Ellipta in your body to be too high, increasing your risk for side effects. (To learn more, see the "Trelegy Ellipta side effects" section above.)

The following medications are antimicrobials that can interact with Trelegy Ellipta:

• ketoconazole (Nizoral)
• ritonavir (Norvir)
• clarithromycin (Biaxin XL)
• indinavir (Crixivan)
• itraconazole (Sporanox)
• lopinavir (with ritonavir in Kaletra)
• nelfinavir (Viracept)
• saquinavir (Fortovase)
• telithromycin
• voriconazole (Vfend)
• erythromycin (Erythrocin)

If you take any antimicrobial medications, especially the ones in the list above, talk with your doctor. There may be another medication to treat your infection that won't interact with Trelegy Ellipta.

Trelegy Ellipta and certain antidepressant medications

Certain antidepressant medications can interact with Trelegy Ellipta. The combination of these medications can cause a problem with your heart rhythm. Specifically, it's important to avoid taking monoamine oxidase inhibitors (MAOIs) or tricyclic antidepressants while you're using Trelegy Ellipta. You should avoid using these medications for at least 2 weeks before you start Trelegy Ellipta treatment.

Examples of MAOIs include:

• selegiline (Emsam, Zelapar)
• isocarboxazid (Marplan)
• phenelzine (Nardil)
• tranylcypromine (Parnate)

Examples of tricyclic antidepressants include:

• amitriptyline
• desipramine (Norpramin)
• doxepin (Silenor)
• imipramine (Tofranil)
• nortriptyline (Pamelor)

If you're taking an antidepressant, talk with your doctor before you start using Trelegy Ellipta. They may suggest other medications.

Trelegy Ellipta and drugs that may affect your heart rhythm

Some drugs can prolong (lengthen) a part of your heart rhythm called the QT interval. Because Trelegy Ellipta can also affect your heart rhythm, you shouldn't take these medications while using Trelegy Ellipta. You should stop taking these medications 2 weeks before you start Trelegy Ellipta treatment.

Other drugs that may prolong your QT interval include:

• Certain heart medications, such as:
  • amiodarone (Nexterone, Pacerone)
  • sotalol (Betapace, Sotylize)
  • quinidine
  • procainamide
  • dofetilide (Tikosyn)
• Certain antibiotics, such as:
  • levofloxacin (Levaquin)
  • ciprofloxacin (Cipro)
  • moxifloxacin (Avelox)
• Certain antipsychotics, such as:
  • haloperidol (Haldol)
  • quetiapine (Seroquel)
  • ziprasidone (Geodon)
• Other medications:

If you take any of these medications or other drugs for your heart rhythm, talk with your doctor before you start Trelegy Ellipta treatment. They may have alternate medications that don't interact with Trelegy Ellipta.

Trelegy Ellipta and certain diuretics

A diuretic (water pill) helps your body get rid of extra water and salt. A certain type of diuretic called a non-potassium sparing diuretic can cause a decrease in your potassium level. Because Trelegy Ellipta can also decrease your potassium level, the combination of these medications can be dangerous. If your potassium level gets too low, you can have heart problems such as an irregular heart rhythm (a heartbeat that's too fast, too slow, or uneven).

Examples of non-potassium sparing diuretics include:

• hydrochlorothiazide (Microzide)
• indapamide
• bumetanide (Bumex)
• furosemide (Lasix)
• torsemide (Demadex)
• ethacrynic acid (Edecrin)

If you're taking a non-potassium sparing diuretic, tell your doctor before you start using Trelegy Ellipta. They may be able to recommend a different diuretic.

Trelegy Ellipta and beta-blockers

Beta-blockers are common medications that help decrease blood pressure and steady your heart rhythm. However, beta-blockers can block the effects of Trelegy Ellipta and cause the medication to not work properly. Beta-blockers can also increase the risk of bronchospasm (sudden trouble breathing) in people with chronic obstructive pulmonary disease (COPD) or asthma. You shouldn't take beta-blockers while you're using Trelegy Ellipta.

Examples of beta-blockers include:

• propranolol (Inderal, Innopran XL)
• carvedilol (Coreg)
• labetalol (Trandate)
• nadolol (Corgard)
• metoprolol (Toprol XL, Lopressor)

If you're taking a beta-blocker, tell your doctor before you start using Trelegy Ellipta. They may suggest a medication other than a beta-blocker.

Trelegy Ellipta and herbs and supplements

There aren't any herbs or supplements that have been specifically reported to interact with Trelegy Ellipta. However, you should still check with your doctor or pharmacist before using any of these products while taking Trelegy Ellipta.

Trelegy Ellipta and foods

There aren't any foods that have been specifically reported to interact with Trelegy Ellipta. If you have any questions about eating certain foods with Trelegy Ellipta, talk with your doctor.